Serenin Vet® (45ct) [FSV]

Serenin Vet® combines different ingredients that work together to promote normal behavioral patterns and a healthy nervous system, particularly in times of stress. These ingredients work together to achieve this calming effect and include:

• St. John’s Wort extract, to promote normal behavioral patterns and functioning of the brain and nervous system.
• Eleuthero powder, to support behavioral responses to stress.
• Passion flower extract, which promotes relaxation.
• DL-phenylalanine, an essential amino acid that promotes normal behavior and attention and balances temperament.
• 5-HTP (Griffonia simplicifolia seed), from an African evergreen climbing shrub, promotes calming behaviors by supporting a normal nervous system response to stress.

Special Note: If your animal is pregnant or actively breeding, or is receiving any medications for behavioral management, please contact our Veterinary Consultants or call us at 1-800-721-1310, or contact your veterinarian before using this supplement.

Download the Material Safety Data Sheet for Serenin Vet™ here!

Do not use Serenin Vet® if animal is on a Monoamine Oxidase Inhibitor (MAOI) or other type of antidepressant. Administer during or after the animal has eaten to reduce the incidence of gastrointestinal upset.

St. John’s wort in Serenin Vet® is metabolized by the Cytochrome P450 liver pathway similar to CBD. Therefore, if taking both supplements, contact us.

Active Ingredients

Amount Per Serving

St. John's Wort Extract (Hypericum perforatum)(Flower Heads) standardized for 0.3% Hypericin 1.8mg / 300 mg

Inositol / 50 mg

Magnesium (Magnesium Oxide) / 50 mg

Eleuthero Powder (Eleutherococcus senticosus) (Rhizome) / 35 mg

Passion Flower Extract (Passiflora incamata) (Aerial Parts) standardized for > 3.5% flavonoids as Isovitexin 1.75 mg / 25 mg

DL-Phenylalanine / 25 mg

5-HTP L-5-hydroxy-tryptophan (Griffonia simplicifolia) (Seed) / 12.5 mg

Vitamin B-6 (Pyridoxine HCI) / 12.5 mg

L-Tyrosine / 5 mg

Folate (Folic Acid) / 200 mcg

Vitamin B-12 (Cyanocobalamin) / 100 mcg

Selenium (Selenium Amino Acid Chelate) / 35 mcg

Inactive Ingredients

Rice flour, gelatin, magnesium stearate, silica

Serenin Vet® combines different ingredients that work together to promote normal behavioral patterns and a healthy nervous system, particularly in times of stress. These ingredients work together to achieve this calming effect and include:

• St. John’s Wort extract, with active constituents hyperforin and hypericin, promotes healthy mentation and behavioral patterns by modulating serotonin, dopamine, and norepinephrine; reducing serotonin reuptake in the brain; and inhibiting GABA ligand binding.(1)
• Eleuthero powder, an adaptogen, aids in the body’s ability to cope with environmental stress and anxiety by modulating the nitric oxide and cortisol production via the hypothalamic-pituitary axis.(2)
• Passion flower extract, containing flavonoids and alkaloids, promotes relaxation by inhibiting GABA uptake by nerve cell synapses.(3)
• DL-phenylalanine, an essential amino acid, promotes normal mood and behavior by maintaining healthy amounts of norepinephrine, as it is a precursor for the neurotransmitter’s production. DL-phenylalanine’s conversion to the neuromodulator 2-phenylethylamine also helps encourage brain neuron receptor sensitivity.(4)
• 5-HTP (Griffonia simplicifolia seed), a metabolite produced from the essential amino acid L-tryptophan and a direct precursor for serotonin production in the CNS that promotes serotonin production and thereby healthy behavioral responses in times of stress.(5)

References

(1) Butterweck V, Wall A, Lieflander-Wulf U, Winterhoff H, and Nahrstedt A. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry. 1997; 30(Suppl 2): 117-124.

(2) Wilson L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, Panax ginseng, Rhodiola rosea, Schisandra chinensis, and Withania somnifera. Australian Journal of Medical Herbalism. 2007; 19(3): 126-131.

(3) Appel K, Rose T, Fiebich B, Kammler T, Hoffman C, and Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passifora incarnata L. Phytother Res. 2011; 25(6): 838-843.

(4) Kravitz HM, Sabelli HC, and Fawcett J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath Assoc. 1984; 84(1 Suppl): 119-123.

(5) Birdsall TC. 5-Hydroxytryptophan: A clinically effective serotonin precursor. Altern Med Rev. 1998; 3: 271-280.